Liver Values Wacky, Not Eating, Lethargic; Going On 1 Week, Vet Not Helpful

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Shar371

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Hey all, new to the forums...I've seen a lot of helpful stories, and I want another take on what's going on with my sweet girl.

She was a street rescue at 4 months, and is now 4.5 years (indoor-only). She was diagnosed FeLV+ on 9/1/2017 (SNAP test only) when I took her to a new vet (we had to evacuate after a hurricane, and I wanted her looked over since she developed a sneeze.)

On 10/30, I noticed she hadn't touched her food all day, was very lethargic, and wasn't interested in playing, treats, or water so I made an appointment with her vet for 10/31. There was no litterbox output on 10/30 or 10/31. She got a Covenia shot, a B12 shot and instructions to monitor for food intake. She'd lost a pound from her September check-up. I worked from home the next day, where we got some small urine output, but it was unusually dark. After talking to her vet, I took her to an animal hospital for a blood draw and urinalysis. They also gave her Cerenia for nausea, added Orbax and Mirtazapine (given two hours later, at home) for appetite stimulation. She drank a little bit, but was still lethargic and not eating.

By Saturday, 11/4, she was dehydrated, and not moving at all, so I took her back to the animal hospital. They gave her another Cerenia injection and sent me home with subcutaneous fluids. She perked up a little after the first administration, but was down again by Monday. She smelled food as I tried an assisted feed and dry heaved, so I took her back to the animal hospital, saw a third vet who broached whether this was her FeLV killing her. He hadn't looked at her lab work, so I pulled it out. Her WBC and RBC are in range (WBC is on the high end of normal), but her liver enzymes and bilirubin are out of whack (AST is 908, ALT 2070, Total Bilirubin 0.9, WBC 15.4). She was down another pound (from 8.13 to 7.12 lbs in about 5 days). He sent us home with another Cerenia shot, a new antibiotic (Zenequin) and instructions to continue fluids and monitor for three days.

I called my regular vet this morning to fill her in on what all has transpired this weekend, and to say that I still don't have a diagnosis and I'm not really happy with the "wait and watch" approach while my cat basically starves to death. She's referred me to a specialist (internal medicine), for tomorrow morning. At this point, my big fear is that the lack of food is causing hepatic lipidosis, or some other complication that /could/ be treated and keep her quality of life high for another year or two, at least.

The questions I'm posing to anyone out here are 1) What bases do I need this new vet to cover, besides getting a diagnosis as to the cause of elevated liver enzymes and anorexia? 2) Has anyone been through something like this, and can you give me some insight as to outcome or treatment plans that you tried? 3) Should I have the specialist confirm FeLV through blood work rather than relying on the SNAP test results? The hospital vets don't seem to be focused on palliative care, or on getting her to eat, just on either getting her to take an antibiotic or putting her to sleep, which seems a drastic swing 4) At this point, should I consider an at-home feeding tube to get her strength back? There have been moments during the past week where the fluids have kicked in, or she's nibbled some food and started to come back to "her old self", which makes me think that recovery could be possible.
 

mrsgreenjeens

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I suspect the cause of the elevated liver enzymes IS the beginnings of Hepatic Lipidosis :frown:. This happened to one of my cats. WHY he stopped eating in the first place we never knew...he just did. But it turned into H/L and he got a feeding tube. I think oftentimes there is no real clinical reason why they stop eating, but once H/L begins, then you've got a problem until their livers get in check again.

I would discuss this with your Vet and if they think H/L is a real possibility, then I think a feeding tube would be of real benefit, along with liver supplements. All the medications you are currently giving can go directly into the feeding tube, which should be helpful. Are you keeping her well hydrated with the sub-q fluids? When you said her urine was dark, this was my immediate thought, that she was dehydrated. I was surprised that she didn't get sub-q fluids THEN, not a few days later :sigh:.

I just noticed that you actually posted this yesterday...does that mean you have already been to the specialist today? What did they say?

:vibes::vibes::vibes:for your sweet girl.
 
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Shar371

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Once I saw your signature, I knew I'd been reading your posts on H/L before... and your stories and responses were one of the reasons I kept pushing so hard. Thank you for posting them! Yes, we've been to the specialist. He asked me to leave her with them for the day so they can run more labs, do an ultrasound and possibly an FNA. I'm waiting for a call back. Thank goodness for a somewhat flexible job schedule.

Specialist agrees that it's H/L, but he wants to find an underlying cause since she's FeLV+. He's going to do a second ELISA to confirm. If it turns out she has FIP or lymphoma, we're going to have a very different conversation than if it's cholangiohepatitis (which will probably respond well to antibiotics or steroids). I have a friend who is a vet tech (BLESS HER), who has been helping me with SubQs. Last night, she also helped me get some A/D slurry force-fed, along with her pills. This morning (after two night-time doses of Zenaquil), my girl was more active, vocal (she found her meow), and even nibbled a little of her dry food before we went to the vet. I've got my fingers crossed.

Lessons learned: 1) Force-feeding is not a good plan for more than a stop-gap feeding (like...once, just enough to get them to the vet). 2) Sometimes, "try this, monitor for three days, and then *shrug*" is NOT a satisfactory answer from a vet. When your cat isn't eating is one of those times. It's been over a week, and this could have been addressed a lot sooner
 

mrsgreenjeens

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Let's pray it's not FIP. There is one cat currently here on TCS that is FeLV and going thru chemo for Lymphoma since she's just 1.5 years old. She's doing very well! So, if it's that, depending on the situation, and which type of Lymphoma, it might not be an instant death sentence. Let's just hope it's neither one of those :crossfingers:

Hang in there :alright: Let us know what they say after more tests are run.
 
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Shar371

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Well, there's the good and the bad.

The good; very little fluid in her abdomen, which seems to indicate that it isn't FIP. Small little happy dance! The specialist said that her liver looked "bright" on the ultrasound, which goes along with H/L... but, he expected a dark liver for hepatitis or lymphoma. He did confirm H/L, and when I mentioned that I was miffed that the /other/ animal hospital had brushed off my concerns, he confirmed my thoughts... Yes, healthy-weight cats CAN get H/L, and yes, she'd been there for a couple of days now, and it could have been caught sooner. She can still bounce back, with help.

The bad; her clotting factors/coag panel didn't look so great, so he didn't want to stick a needle in her liver for the FNA. He gave her a shot of Vitamin K, with the hopes that it improves her enough for him to try again in the morning. That test should give a better indicator of lymphoma v. hepatitis. Her spleen has what he referred to as "pathologies", and her second ELISA (now 9 weeks after the first) came back with a strong positive for FeLV.

Bouncing back to the good...First thing out of the carrier, she made a beeline for her food bowl and her new raised water dish (She's a "novelty water" drinker... has to have a taste out of every faucet, glass, spilled drop...So I try to keep her entertained, in sickness and in health). She had about four of the crunchy dairy treats before heading back to her new favorite resting spot. She's periodically getting up for water, and I'm going to try some wet food after I get her Zenequin in her.

Although I talked to the specialist about going ahead with an E tube, I'm second guessing that now that she's showing some appetite returning. He had alternatively recommended a PEG tube (which I saw as a little too extreme for Midnight's case), or using steroids to stimulate her appetite. I'll give the guy credit, he did present my options, and made sure I was up on the causes, prognoses, etc. for each of the possibilities.
 

mrsgreenjeens

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If she can handle an e-tube, clotting wise, that may still be your best bet, simply because you already said she doesn't take force feeding well, and even though she is showing interest in food, with H/L she probably will not eat enough to keep her going. Often with H/L even when they begin again to eat on their own, they still need to be fed thru their tubes as well, just to get enough nourishment. I know you'll have more discussion about this with the Vet once the diagnosis is made pm what caused it in the first place.

:vibes::vibes::vibes:
 
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Shar371

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Thank you for the vibes, MrsGreenJeens! Her clotting factors still aren't so grand for a tube, and both the specialist and another vet he called for a consult to double check decided it wasn't worth the risk, especially if she was starting to eat on her own again. We're going to try the steroid route over the weekend, and see how she does. The good news is that the specialist is also with the better of the 24/7 emergency vets in the area, so if she starts to look like things are taking a turn again, all of her records are already on file, and they know her. They did go ahead at get the FNAs of her liver and spleen, sent those off for testing, and are keeping her through this afternoon to make darn sure there are no bleeding problems.

We're going to sit and talk when I pick her up, and I want to float some ideas past him to entice her to eat. I've heard about Fortiflora and Kraft Parmesan ("the green can!", which I kinda giggle at seeing on the boards), and I'm going to try kitten kibble (she was super cheesed off at me when I started transitioning her to adult food three years ago...Maybe she'll cheer up to see it again?). I also want to check about continuing the SubQ fluids, because as annoyed as she was to get a needle in her back, she always seemed to perk up a bit and have a little appetite afterwards.

In case anyone else stumbles across this someday looking for the same stuff I was, the steroids come with risks... because she's FeLV positive, they may open her up to other infections, which could use the steroids to run rampant. They're also going to make her lethargic, which is going to scare the knickers off of me. One of the bigger concerns for the average pet owner is that the pet may overeat suddenly, or become rapidly obese... in may case, I'm going to have to watch for re-feeding syndrome (basically, that she eats too much, too fast, which would cause a system shock after so long NOT eating... this is the same reason you slowly ramp up what you would feed kitty through tube feeding), and monitor for weight gain. Lastly, if they had given her the steroids before they did the FNA, they could have messed with the results, throwing off certain values.
 

mrsgreenjeens

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You are very well versed in your cat's health issues, and possible future issues. Good for you!! :worship: You are right on with everything I have read from you so far.

Your little girl is in good hands :hugs:
 
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Shar371

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I wish I could agree...

I was feeling hopeful when I picked her up from the specialist. The prognosis was guarded, yes. I get it; It's been a while, she's FeLV+, she's very sick... but the specialist made it clear that he felt the steroids would show their worth within 48 hours, her appetite would improve, and we'd have the results of the tests by the end of the day tomorrow. He wanted me to monitor her for a week, and then e-mail him back with how she was doing. We talked about caloric intake, how to get there, what to watch for ("Pretty much, make sure she doesn't have a seizure, or stop eating entirely") and then he left.

The problems started at check out, when I asked for copies of the radiographs for my insurance company. They hesitated. Then they said they'd e-mail them to me (mind, this facility and I had never communicated by e-mail), and then they handed me a "discharge summary", said that "usually was good enough" and sent us on our way after I paid. Ok, I was eager to get Midnight home, settled, dosed, and fed. She had been happy to see me, and had eaten a couple of treats right there in her crate. Yay!

I get her out of her crate at home and notice her limping out. Then I see the bright blue wrap tight around her right rear leg. Yep, they left a compression bandage on her leg all afternoon. I called and got the clearance to remove it, after adding that they hadn't told me it was still there to begin with.

About an hour ago, I finally read through the discharge report. It had some surprises that the specialist hadn't discussed with me. Things like "fractured 10th rib", and "air in thoracic esophagus". By this point, I was already sick to my stomach, and then I saw "refused E-tube treatment" followed by "prognosis grave".

So... I've now had a good cry, dashed off a panicked e-mail to my insurance company's vet helpline, basically laying it all out like, "Ok, I've done everything by the book, and I'm getting stymied at every turn, what now?" I can't seem to get anywhere with getting Midnight better, and all my efforts seem to be making it worse for her. I'm absolutely heart sick and don't know what to do anymore
 

mrsgreenjeens

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Oh no! Have you called the Vet's office this morning and asked what on earth this is all about? (and I'm so sorry, I'm about ready to leave for a long weekend away, so am not going to be any good to you, even just as a shoulder to cry on :frown: )

:vibes::vibes::vibes:
 
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Shar371

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I've pretty much made up my mind on this, with the help of my vet tech friend... We're going to give the steroids the weekend, with observation. Specialist should get me the results of the FNA late today, at which point, I'm going to request her full records from that facility and take them to vet tech friend's employer (further away, but she, and they, have been the ones giving me fantastic advice all along, and led me to researching tube feeding in the first place, which led me here). I'm going to make an appointment for Monday for the tube, with them, come hell or high water.

I calmed down enough to re-read the discharge report, and saw that the fracture's edges were "rounded and apposed [sic]", which I'm assuming means it's an older fracture that's healed, probably from whatever tore her up as a kitten (when she was found, she was in rough shape, but none of the records from her fosters show a fractured rib). I'm still concerned that he didn't raise it with me, since I gave them full access to her records, and it wasn't in there.

I've enlisted my psuedo-parents to check on her while I'm at work and to try to tempt her with treats (they're also my folks who can step in for feedings for the tube, and they're up on the situation).

Thank you so much for all your help MrsGreenJeens, have a good weekend away!
 
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Shar371

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This will be my final update, as to Midnight's condition.

We got the results back from the FNA (liver, spleen)... Not cancerous, positive for hepatic lipidosis. (No kidding...) He advised, again, that if she doesn't improve over the weekend, to bring her back for a tube. I had already made an appointment for 11am Monday with my vet-tech friend's vet to do the tube placement. I requested full records for Midnight in order to get those to them.

Friday night, and I still can't get her to eat. I was determined to forcefeed her as necessary to get her to Monday. Vet Tech friend comes over and, basically, says she doesn't think that Midnight will last the weekend. We both rush her to yet another emergency vet (the ones her vet clinic uses and refers to, rather than either of the two I'd been to before). I fill them in, give them full access to her records. She's... she's just not having any of this. Freaking out, fighting with everyone. Vet Tech friend had to go home (by the time we finally got the vet to see us, come around to the E-Tube idea, it was 1 am, she had to be up at 7), and I was determined to stay until the tube was place, even if they had to keep her hospitalized. Best decision I made in this whole deal.

ER Vet re-drew blood and tested CBC... Big changes, for the worse. She was now anemic, very low platelets, very high WBC (97) (That's very unusual for FeLV...but not for cancer). He ultimately determined that she had cancer in her bone marrow. The only way to confirm would be a bone marrow biopsy, and she'd been giving them hell in the back (I could hear her screaming the entire time). I decided to cancel the tube and take her home. It was about 3 am when we got home. I got her settled, started my research... found out that ER vet was exactly right. Even with full treatment, her odds weren't great, and might buy her, at best, 6 months of low-quality-of-life survival.

I called Lap of Love the next morning to schedule. They had nothing available for Saturday, but Midnight didn't seem to be in any pain. She was tired, but she could still get up and go to her water dish and come back. I took their first available, 11 am on Sunday.

Midnight slid downhill rapidly from Saturday night on. She ultimately died in my bed, nose to nose with me while I stroked her head. She had been struggling to breathe, and her eyes had already glazed over, her gums had gone blue. The euthanasia vet was running late, and arrived a little before noon. Midnight passed around 11:20.

Anyone who comes across this, looking for answers, be it days, weeks, or years from now... Get your cat eating again. If I ever have this happen again, to me, or a friend... I'll be more forceful, and insist on an e-Tube within the first week. I'll also ask for follow-up blood work.

It might not have saved Midnight's life in the long run, but it would have saved her this morning's pain, seizures, and struggling for breath.
 

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I'm as devasted as you at reading this last update. I was reading your thread, but not replying because I hadn't any advice to give.
I'm so sorry for how the story ended...
But you had a beautiful final hour together, nose to nose, without strangers to ruin your bond.
RIP Midnight :(
 
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