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Or possibly the Prednicare has impact on the mass, therefore it feels differently for him?The most common side effects of pred are increased appetite and drinking, sometimes urination. There are other side effects at high doses or that occur with long term use. If this was a 2 day prescription, I don't think that what you are seeing is related to the medication, but I am not a vet, so this is only my opinion.
I think that the mass in his mouth is causing the problems.