Kitten Health Crisis- Looking For Similar Experiences To Add To Knowledge!

Catsnkiddos

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In July we unexpectedly took in a litter of 3 kittens from someone's yard. They were flea infested, to the extent that I initially thought they were dead. Their gums AND tongues were white. We spent weeks washing them several times a day with dawn and picking off fleas with tweezers. At first we had to bottle feed them (they were pretty young). The vet prescribed Clavamox for all 3 as 2 clearly had upper respiratory infections and wormed them. We took them to the vet right when we first brought them in and they were snap tested for leukemia, immunodeficiency and parvo- all were negative. It took a long time to clear up the upper respiratory and to get them on the right track. Our vet recommended delaying vax until we spayed/neutered which would be when they were healthy.

The kittens have been thriving. They are energetic, curious and growing. I had them scheduled for spay/neuter in about a week. This past Monday, the most energetic and funny male rejected breakfast (they are food fiends) and went to the litter box...then back to my bed. I was concerned and called my vet. He suggested I monitor and if he still seemed off to bring him in the next day. About an hour later the little female seemed to be lethargic as well. By the end of the day, something was clearly seriously wrong. They were not opening their eyes...were laying in one spot...and when I took the male to the litter box he had white diarrhea down me. I rushed them to the only open vet (not my usual vet). She repeated SNAP tests for same big 3 and all were negative. She ran a CBC and gave fluids. The male's temp was 103.9 and the female 105.8. I rushed them to an animal er where they could be admitted. In the 35 minutes it took to drive from one place to another the temps went to male- 106 and female 108. They rushed her into isolation and started immediate fluids. The vet at the first location felt we may have received a false negative for parvo and that the cats had panleukopenia- the ER hospital was sure it was viral but weren't sure of type.

They remained in isolation from Monday through Thursday receiving fluids, abx and antivirals. The first night there the female ate, but it took a full 24 hours before the male ate. They were reported to be ravenous. They continued to have diarrhea, but fevers came down within in 36 hours to normal temperature. At one point the female went below normal, but not enough to warrant anything more than monitoring and by next temp taking was normal range again. One of the ER vets said he felt that with such rapid response it was unlikely to be panleukopenia but was most certainly viral. On Thursday night they finally said I could pick them up. They reported they were bright, energetic and eating. They wanted to repeat bloodwork at discharge and have a pathologist review as the initial blood had been VERY alarming (low white blood cells, low platelets, low red count). I was sent home with metronidazole, clavamox, famciclovir, and a probiotic. I was told to isolate them from other kitties for 14 days. It was deemed fever of unknown origin with a likely viral cause.

They were VERY happy to be home. They stretched and frisked and played. They raced around their isolation room, scratching everything. They attacked my toes all night- essentially they returned to soccer hooligan mischief. They still had diarrhea, but they looked like they were recovering.

Last night the vet called with the pathology report from discharge bloodwork. The white cells are still way down as are platelets. Most alarming, the female's red blood cell count was at 18% and the male at 20%. They said the blood is not regenerating pointing to an issue with the marrow. They mentioned feline leukemia as a possibility again. They said it could be a very aggressive cancer. They mentioned a few other possibilities, all of which seemed to mean inevitable death very soon.

They are running another test on the blood they still have...and want to do a marrow aspirate immediately. I had to pick up doxycycline (they have to compound it as the kittens are small) and started it this morning.

Meanwhile they are running about...wrestling with me, climbing me. They seem a bit bored locked in my bed room but in good spirits. They love to play king of the hill climbing the back of the desk chair. The female has always just stayed on the chair seat and gotten her brothers, but she actually climbed to the top- they seem healthier than ever when just looking at behavior. They still have diarrhea...but not non stop. It is not that white liquid from Monday....it is a good color and for the female still very runny, but for the male a little formed. Their noses are wet, eyes bright.

Has anyone ever had something similar with their cats? Did they survive? Was it ever not one of those big three? Is it always a death sentence when they present with this? If your cat had panleukopenia, did they have similar symptoms/manifestations? Was is something maybe my vets have not considered? Could it be a toxin (vet says toxins never have fever, but...). I am hoping to hera broad feedback to help make my conversations with the vet team more productive. I am researching online as well, but would appreciate any input.

A quick add on- since giving the doxy they seem a little more lethargic. I have tried to increase wet food feedings to help with hydration. They are perky when I wake them...but they want to sleep. On the one hand of course you sleep when you are sick..but on the other I am afraid they will succumb at any moment! I am SOOOO worried.
 

Blakeney Green

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We've been having a similar issue at the shelter. The vet thinks it may be a mutated strain of panleukopenia that comes up negative on a parvo test. We don't have any definitive answers yet as we are still waiting for lab results and final necropsy reports, but if anything useful comes back that you may be able to pass on to your vet, I'll let you know.

I will say that for the cats we've seen this in, everyone who has survived the initial crisis has lived.
 
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Catsnkiddos

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That makes me feel a bit better. I felt like if they have made it nearly 7 days since symptom onset it should be hopeful....but the non-regenerative anemia is really a scary result. They pretty much have diarrhea immediately after eating..and until the sleepiness this evening had no other sign of being ill. It seemed so strange that both had acute symptom onset the same day...and their littermate s just fine (in fact he is crying at the door to get to them). The vet call last night makes me think they are going to die any moment and I feel like I am on pins and needles. They want to do a marrow aspirate on Tuesday and are doing a PCR blood test on the remaining samples from Thursday.
 
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Catsnkiddos

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I am also hoping we can talk about B supplements and maybe epogen or procrit to help kick start the marrow when we go in on Tuesday
 

rubysmama

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So sorry to read about your kittens and their mysterious ill health. Because they are kittens, it's possible our "kitten advisers" may have some ideas / suggestions, so I am going to add them in. StefanZ StefanZ Sarthur2 Sarthur2
 

StefanZ

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I dont know much here. From overall advices, you comtnue with pedialyte? Can you get taw goats milk? This sometimes an edge. Being extra useful. I agree prob. Something viral. OR toxic as both got it somultaneusly. Idea: perhaps smething they got through the fleas? I know tics can transmit several diseases to humans. Maybe to cats too even if its. Not wellknown.
 

StefanZ

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Another one, admittely wild idea. Is it possible they could get into them something radioactive "radiac-poisoning"? A rather big dose in one occasion.

It too could give similiar symptoms, including a period of well being, before next phase comes.

Were there fur falling out extra much?
 

Sarthur2

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Catsnkiddos Catsnkiddos

Doxycycline is strong. What are they taking it for? It could make them feel lethargic.

Are the kittens still on the other meds too? If so, which ones?

It sounds like the kittens have been improving. How old are they now?

I would strongly suggest vitamin B injections.

Be leery of too many medications and invasive procedures on the part of the vet.

To a certain extent it may be best to give vitamins, fluids, and see how things go since they are now eating and playing well again.

The continued diarrhea is concerning, but medications can contribute to that as well. It also sounds like even the diarrhea is improving.

Has the vet run any fecal tests?
 

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After reading part of the way through I thought they had the form of calici virus nicknamed limping kitten syndrome.
It hits very sudden, kitten has a high fever and only wants to sleep.
However, this is a 3 day virus.

There are various strains of panleuk, and surely new ones not yet familiar to us rescues and shelter staff.
The test for panleuk can most definitely give false negatives, I have seen this many times. The snap test is actually made for dogs and parvo, but parvo and panleuk have some similar makeups so the snap test can be used for cat panleuk but not fool-proof by a long shot.

FELV could certainly be the cause of the lack of cell production. Were the kittens each given their own snap test for felv with their own blood?
Sounds like a strange question but some vets will 'batch test' from same litter.

FELV in young kittens comes from their mama. Do you know who/where she is?

I need to think on this one for a bit. Not symptoms that scream one specific thing like is typical in kittens....hmm.
 
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Catsnkiddos

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Sorry for not coming back- I was waiting for our veterinary appointments and results. The call on that Saturday night was from one of the vets that had been overseeing them while they were in the ER isolation unit (they had one dr during the day another overnight). She really was doom and gloom and insisted that due to the decreasing red cell count they had on regenerative anemia. With that diagnosis she felt there was certainly an underlying disease like leukemia or an aggressive cancer. I just could not understand how such a low blood count was possible- I mean red cells carry oxygen and I would think a lack of oxygen would not lend itself to frisky kittens- which they have been for the most part since being released from the ER (they spent Monday through Thursday on iv fluids, iv antibiotics and iv metronidazole). That vet indicated they would do a PCR test on the remaining blood samples and then schedule a bone marrow aspirate for this past Tuesday.

We picked up the doxy on Sunday morning and administered it immediately. They got a little lethargic.... and I feared hot. I increased can food feedings to every 2 hours to try to hydrate them (though they were drinking) and they seemed to perk up immediately after eating. They continued diarrhea- in fact each time they ate they immediately defecated, sometimes having to stop mid meal to poop then go back to eating. It was super stinky and very runny.

On Monday night i noticed they did not have diarrhea after their 7 pm meal....in fact though they urinated (a lot) and did not defecate until the next day, mid morning. It was still soft, but less stinky. Since then, they have reduced frequency of defecation, but when they do it is still soft and occasionally very stinky. Only once since Monday has it occurred in conjunction with eating.

On Tuesday we saw the critical care specialist who was to do the marrow aspirate. The PCR test had not been executed so there were no results. The doctor did a very thorough exam. Their temps were normal. They had BOTH gained weight. Their gums were healthier looking (not perfect yet, but better), heart rates good...everything where it should be. They were very relaxed, and super friendly. They watched out the windows of the exam room, attacked the cursor on the computer screen, climbed the doctor's leg...were their lovey hooligan selves. They explored, romped, were kitten essentially. The doctor was quite surprised. He told me he did not expect to see such healthy cats based on the blood work and case history. He told me he could not explain what he was seeing. He said Luna's blood work had last shown 16% redblood cell count..and by his exam he felt she was at least a 20-25% level. He decided to repeat the CBC and run the PCR that had not been done. He said based on the results we would do the marrow aspirate...but he thought it would be unlikely.

Last night the Dr called, and said the rbc had increased- it was still very low but was headed in the right direction! He says we must continue the medication regiment and continue to monitor them. We will repeat bloodwork in 2 weeks. I don't understand how we go from leukemia and aggressive cancer on Saturday night to hey, looks good today! I am still worried and waiting for the other shoe to drop...

Kitties have to continue meds- clavamox, metronidazole, famcyclovir, fortiflora and doxycycline. If they show 95% state of being better they can come out of isolation prior to end of meds.....
 
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Catsnkiddos

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To address some of your posts:
  • The Drs felt this was not a toxin as there were high fevers. They felt strong that precluded poison/toxin ingestion or exposure and pointed to infection
  • Since they were so flea covered when found I certainly feel this could be flea related...or even passed from mother who is unknown
  • Fur did not fall out- it has remained soft and glossy
  • Doxcycline was added but for what was not specified- it was after the PCr was suggested- they felt either way on the results of the PCR test they would start doxy so they did. When reading about the things PCR tests for I can see why this would be prescribed.
  • The kittens are now on fortiflora in the first canned food of the morning. They also receive their clavamox (both get .5ml liquid) and famcyclivir (1/4 of 60 mg tablets), and metronidazole (.3m ml liquid). 2 hours later with their next canned food feeding they get the doxycycline (.20 for Luna, .24 for Atticus liquid). They get the morning meds (clavamox, metronidazole and famicyclivir) 12 hours after the first dose.
  • I am not sure of their exact age. We found them on 7/19 and had to bottle feed them. Local shelter told me they were about 3 or 4 weeks at that time. I am guessing they are about 4 months/4.5 months
  • SNAP tests and fecal test have been done for each kitten. All have consistently been negative for everything. Mother and her status is unknown. These are foundlings, not from my yard/neighborhood, etc.
 

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Sounds like things are getting better. Fingers crossed for continued improvements. :crossfingers:
 

Blakeney Green

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I don't understand how we go from leukemia and aggressive cancer on Saturday night to hey, looks good today! I am still worried and waiting for the other shoe to drop...
This really does sound like exactly what we had. The other shoe never dropped. The survivors are still doing great.

So glad to hear your kittens are doing better! :)
 
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Catsnkiddos

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That makes me feel better to hear. THanks for sharing that!
 
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Catsnkiddos

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Well...this morning Atticus Catticus was not himself...he didn't come over for morning canned food. I put him in front of his bowl, he ate very little...then went to lay in a little ball. I brought him to my room where he has been all day. He does not have a fever...but he is squinty eyed and lethargic. I have been giving him water every 15 minutes via syringe as he won't drink from the offered bowl. A few hours ago I brought in some canned food and he would lick a little off the end of the spoon. He has groomed a little...and has been laying with his back legs stretched out. He has twisted upside down a few times- I thought just sour stomach (no masses on palpation). He just hopped off the bed and made a sound of pain as he landed. He went into my closet so I took him to his litter box. He didn't strain..but the poo was WHITE again and very much liquid like when this started in October. (The other cat was licking his bum earlier just like last time- I should have known). I am panicked that this will take a turn for the worse. I am monitoring him and read to call the vet if I have to... For the person who mentioned this ripping through the shelter did you have any relapses like this? Could it be a relapse? Could it have always been something else underlying that they just never caught? Mind in a tailspin. So sudden again...he was running like a wild kitten at 2 am when I finally fell asleep...it was 5:30 when I first got up and he seemed to be not so peppy....
 
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Catsnkiddos

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Just to add- gums are nice and pink... no fever....
 

Blakeney Green

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For the person who mentioned this ripping through the shelter did you have any relapses like this? Could it be a relapse?
We didn't have any relapses. All the survivors of the initial outbreak regained their health. Necropsy results on the kittens who didn't make it confirmed a panleukopenia strain that was too mutated to show up on the SNAP parvo test.

It's possible that we didn't have the same thing you have, the symptoms just sounded really similar. I hope your kitten feels better soon!
 
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Catsnkiddos

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My own vet was convinced it was panleukopenia when he reviewed all the hospital records, so I thought you were spot on. I wonder if he ate something. He wants to lay on his side and stretch his back legs out or twist belly up. I just gave him more canned food- he tried to lick it off the spoon so there is a tiny bit of interest in eating (won't take it from the bowl). I gave him the most miniscule amount just to see it he would eat. I am continuing the water by syringe and he seems happy enough to take it. As I was typing he just mewed a sad mew after wiggling around a bit. I think his stomach is really bothering him.
 

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How is he today?

If he is not eating he needs sub-q fluids from the vet asap!

You can also try Gerber turkey baby food on a plate or spoon.

Also, give unflavored pedialyte instead of water. He needs the electrolytes.

White poop can indicate liver problems.
 
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