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Twyla was going hypothyroid on the twice a day hence the once a day dosing. My vet didn’t think it was feasible to split the pills into eighths so we tried once a day, which worked great for six months.I have a pill splitter that works pretty well to divide Felimazole into quarters (not the same one I use for amlodipine). Besides, Feeby gets it twice a day, so if I am a tad off, it is more or less made up for with the second dose. I don't understand the only once a day dosing for the thyroid meds; twice daily keeps the med at a more even keel throughout a 24 hour period. Just what I have read and what my vet thought was best.
Right now, due to Feeby's med schedule, she gets amlodipine around 3PM. I only did this because there are just so many pills I can get down Feeby at a time, and she was already on an AM/PM schedule for her Felimazole and her ondansetron. So, I just split the difference in the day to administer amlodipine (0.625 mg). Feeby's BP, at last check, averaged between 150-160.