Odo and possible IBD

cloud_shade

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I haven't posted about my own kitties in a while, and I'm hoping someone might have some feedback or experience that can help.

Odo is my senior kitty. He's at least 14, but probably more like 17 years old. For the last year or so, he's been throwing up. At first it was occasional, but now it's several times per week. Per the vet's advice, I tried Pepcid. It didn't seem to help.

Last July, his BUN and creatinine were slightly elevated and his neutrophils were a little high, as was his amylase level. His urine was dilute with a specific gravity of 1.015. We figured he was in early renal failure. He also had some mucus in his stool, but he didn't seem to be constipated, and his stool was solid. I tried Pepcid again and liquid Zantac (not at the same time). Neither seemed to make much difference.

The vet recommended seeing a specialist, and I finally took him in last week. The specialist did an ultrasound and found several "interesting" things, though we don't know for certain what any of them mean. The most interesting of them is that his gallbladder is of normal size but his cystic duct is very dilated. She didn't find any reason for it to be dilated--no mass, no stone, and no other sign of blockage. She could see the left side of his pancreas but not the right side. There were nodules in his liver, but she couldn't say what they were. His small intestine looked normal (not thickened), as did his colon, but there was a nodule near the junction of the two that she suspects is a lymph node (and possibly the reason for the mucus in his stool). His kidneys are a little bit small and have a hyperechoic corticomedullary band (which she said is consistent with chronic kidney disease).

I also had his bloodwork repeated at my regular vet's office. Odo's ALT, BUN, and creatinine are all within the normal range. His amylase is still a little high (1375). His neutrophils are a little higher than they were before (15,573), his lymphocytes are low (716), and his monocytes are high (716). His urine specific gravity dropped a tiny bit to 1.014.

The specialist recommended starting him on ursodiol to improve his bile flow (which I started on Friday evening), since the cystic duct is so dilated. We also started him on prednisone (twice a day, starting Monday morning) to help with suspected inflammation. The specialist wants to do exploratory surgery, but I'm not keen on it--he's an old kitty and I don't want to reduce his quality of life by making him recover from an invasive procedure. The specialist's suspected diagnosis is GI disease or possible triaditis.

If the prednisone is going to help, how long would it take to have an effect? He vomited yesterday and again this morning. Does anything in the report stand out to anyone?
 
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cloud_shade

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*bump* Any idea on the prednisone--how long does it normally take to see an effect?
 

violet

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Part of the problem may respond well to ursodiol. (I don't know how quickly.)

An enlarged lymph node may respond well to treatment with prednisone. If the vet can palpate the lymph node, the difference in size can be noticeable after three weeks of treatment. That would mean the prednisone is helping with inflammation, so you might see other positive signs as well.
 

motoko9

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Originally Posted by cloud_shade

*bump* Any idea on the prednisone--how long does it normally take to see an effect?
I read your post, but didn't respond, because I've never had a cat treated for IBD. (Ironically, I suspect now that one of my RB kitties suffered from it, but that was many years ago, and he was never diagnosed.) I know we have at least a couple of members with experience with this issue, so I'm hoping one of them will see this thread eventually and respond. Best of luck to you and Odo!
 

denice

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Patches also had a badly inflammed liver and probably gallbladder involvement with his last flare of IBD. Thankfully he didn't have the last part of the triad, the pancreas. It took a good 10 days on the pred before there was any real improvement in symptoms and a good two weeks before he seemed to really feel better. His liver panel looked really bad and it took longer for his numbers to begin to look better. They actually continued to get worse after he seemed to feel much better.
 

farleyv

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Just want to send for your kitty. My cat, Arthur, is on Ursodiol for his gall stone and bile duct stone.

I hope your kitty comes around and you find out what is bothering him.
 
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cloud_shade

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Thanks for the the thoughts and vibes. I emailed the vet, and it may take a week or so for Odo to respond to the prednisone. I'll give it more time to see if it will help him. Fortunately, he's super easy to pill, and he loves getting treats and petting afterward.
 
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cloud_shade

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Just thought I'd give an update. After a few months trying Odo on both prednisone and prednisolone (after the initial prednisone prescription ran out, my regular vet switched him to prednisolone), we finally concluded it wasn't helping much. He was still throwing up a couple of times per week. As I weaned him off the prednisolone, I did notice that his back twitches returned. He's had the back twitches for as long as I can remember, and they went away almost entirely while on pred. However, since the medication didn't help with the vomiting, we weaned him off of it to try something else. Last night he got his first doses of metoclopramide and cyclosporine. We'll try that for a couple of months to see if it helps.

Also, I only gave him the Ursodiol for a couple of days. When I gave it to him, he ended up looking really spacey and freaked out. The specialist hadn't heard of that side effect and didn't think it was related, but I got the same result when I tried it a second time for a day. I decided it wasn't worth it to give it to him.
 
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