Looking for any kind of advice: cat not eating, enlarged liver, spleen

av23

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Hi everyone,

This is my first post to this forum. I apologize for the long post, but would really appreciate if anyone shared their experience with cats who had similar symtoms.
About a month ago, we started noticing that our cat (12 y) was not finishing his typical food bowl at meal time. Gradually, his apetite started decreasing to the point of taking a few bites and walking away. After about a week we took him to the vet. They did a physical exam (all clear), and a comprehensive series of blood-work, checking liver, kidneys, pancreas, which all came back clear, expect for low absolute lymphocyte count. We were prescribed anti-nausea medication and mirataz. For about a week his apetite was more or less satisfactory, although he took most of his food only when we hand-fed him.

A week later we went to another vet, who did an ultrasound of his belly. Intestines look fine, kidneys look old, but normal for his age. Pancreas normal. The vet found enlarged "fatty liver" (although blood-work doesnt show liver failure), enlarged spleen and one bigger lymph-node in the belly near the bladder, which they couldnt biopsy because it was "too small" and moving. The vet did however take a biopsy of the spleen, and the cytology results were all clear, no abnormal cells found. We got sent to another vet (internal vet medicine specialist) who suggested simply placing a temporary feeding tube to get him back on track with eating. She said sometimes it is just a matter of eating a bit more and then the cat starts to feel better and we never know what was wrong with them. Since she couldnt perform the operation herself we got sent back to our original clinic, however, on the morning of the scheduled operation, I consulted with the vet who agreed that perhaps it is a bit too soon for a feeding tube, as he IS still eating on his own (even if by handfeeding) and NOT losing any weight. So they re-ran the blood-work and the only thing they found was the same low lymphocyte count. They did suspected a kidney infection upon a quick look at the urine under a microscope, and gave us antibiotics, which we used for several days, but then we got the extensive results of the urine analysis, which were all clear (no bacteria present) so we discontinued antibiotic use.

As a matter of fact, for about 3 days after the last vet visit, it seemed our cat was doing much much much better without any meds at all. I started feeding him Hills recovery canned food, over 5-6 meals he would eat the whole can (156-180 g, no mirataz), plus various snacks, and one day even came down to his bowl in the morning like his usual self. His energy levels seemed good, he was in the balcony the whole day, playing and he didnt look sick until Sunday. I woke up on Sunday, he was laying beside me and I just knew something is wrong. He vomitted up a hairball at night, and then clear liquid shortly after we woke up in the morning (this was not the first time he vomitted clear fluid in the past weeks). He ate about half a can of wet food, but in the afternoon his apetite was completely gone and he didnt eat the rest of the day. Whenever I bring food he just turns away, and if I am being too persistent he just goes to hide from me. We gave him anti-nausea pill, mirataz, but nothing seems to work this time so we are force-feeding him with a syringe now, which is not going well. We are going back to the internal vet medicine specialist tomorrow, to repeat all ultrasounds and perform any necessary tests, but my question is...

Has anyone ever experienced similar symptoms? I am completely terrified he has lymphoma, but wouldn't all of the tests we done would have diagnosed this already? I would be grateful if anyone could share their experience, tips or suggestions. We are just completely beside ourselves..
 

PushPurrCatPaws

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I am so sorry you are going through this with your cat. I wanted to ask, is he pooping/peeing normally?
Also, is the Hills recovery canned food a new food for him, or is it his regular food? If it's a new food, maybe his system is not adjusting very well to its ingredents?
As a matter of fact, for about 3 days after the last vet visit, it seemed our cat was doing much much much better without any meds at all. I started feeding him Hills recovery canned food, over 5-6 meals he would eat the whole can (156-180 g, no mirataz), plus various snacks, and one day even came down to his bowl in the morning like his usual self.
 
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av23

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I am so sorry you are going through this with your cat. I wanted to ask, is he pooping/peeing normally?
Also, is the Hills recovery canned food a new food for him, or is it his regular food? If it's a new food, maybe his system is not adjusting very well to its ingredents?
Hi, thank you so much for responding 🙏...yes, his poop/pee is completely normal, nothing out of the ordinary. The Hills food is completely new to his diet, and indeed I havent thought of the possibility that the food itself might cause issues. Is there anything special I should know about this food? We've never had to give this food to our cats before.
 

FeebysOwner

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Hi. Not exactly the same, but Feeby (17+yo) has a thickened spleen, and enlarged adrenal gland, and some structural changes in her kidneys/ureters - none of these conditions changed between two ultrasounds done last August and again in December. However, on the second ultrasound there were some mildly enlarged lymph nodes in her intestinal area - an FNA cytology was done - no abnormal cells. The vets consider her cytology to suggest some sort of inflammatory condition, and if not that, then IBD or lymphoma. I am pretty sure she does not have IBD since her symptoms are pretty much inappetence and the previous weight loss. They really didn't offer anything specific for this possible inflammatory condition and could only suggest steroids and/or chemo on the chance it might be lymphoma. I chose to wait and have another ultrasound done - which I should be following up on soon now. I am not saying Feeby doesn't have lymphoma, but more and more - with what I read on this site and others - I am getting the impression that IBD or lymphoma is a 'go to' diagnosis when nothing concrete can be determined. I have been repeatedly told that short of a biopsy, lymphoma cannot be confirmed.

She is/has been on and off with her eating, for months now. She has been on Mirataz since last November, but it does not appear to be as effective as it once was. I also tried Cerenia for nausea, but it made no appreciable difference. The vet wanted me to try famotidine for possible acid issues, but I have not been able to get her to take it. The amount of Mirataz is also a balancing act, as I have found out that giving too much can be as problematic as giving too little.

I tell you all of this, not because we have found an answer, but because you asked for commonalities between your cat and others. I also want to point out that I have heard - and, read - low lymphocytes are sometimes 'written off' to old age - not just in cats, but in humans as well. It can also be an effect of long-term stress.

The vomiting of clear fluids - particularly in the early morning hours is often due to acid build up in a cat's stomach if they go too long without eating some food. Feeby was doing this for a while, and it has been resolved by giving her baby food meat (Gerber Stage 2 or Beechnut) late at night and again early in the morning before she gets her breakfast. The baby food meat also helps to add to her calorie count each day. She too wanes from eating in the evenings. So, I too, bring the food to her in the evenings, and sometimes she eats it, other times not. If she rejects it, I try again each half hour following - and oddly enough, that helps to get her to eat some eventually. I do find that adding FortiFlora (a probiotic, but really is more like a food enticer) or her favorite Party Mix treats crumbled up and mixed with her food helps to eat. Recently, I have been giving her some nutritional paste/gel mixed with her PM meds because she stopped eating the meds with one of a number of lickable treats that she has eaten in the past.

The above paragraph is more for you to consider some of the things I have tried that have worked/are working for me, while we both continue to try to figure out what is going on with our cats. I know nothing about the A/D food but am considering trying it with Feeby - not as her entire diet, but just as an aide to help interest her in food and add calories to her regimen.
 
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av23

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Hi. Not exactly the same, but Feeby (17+yo) ....
Thank you for sharing your experience, this is really helpful. Just being able to talk to someone going through something similar is a great support. To be honest, the past month has been a total emotional rollercoaster.

Also, thank you for the baby food meat idea! I will try that tonight, fingers crossed it works. Our vet recommended the the A/D food in this case because it is high in calories, and to be honest our boy was very very into it. In fact, for a few days he preferred this food over anything else we tried to offer him. Since it is a higher calorie food, it did help us tremendously in reaching his recommended daily calorie intake.

Regarding lymphocytes, two of the three vets that we saw were completely unconcerned by it. One said that this is something that they see very often with cats. Another one said it is most likely a stress reaction. However, one vet claimed low lymphocytes might be consistent with lymphoma. That is why tomorrow I will ask the specialists if they can biopsy that slightly enlarged lymphnode, also the liver (if it is possible to do FNA on the liver). I will update as soon as we have the results.

Based on what I've read, lymphoma progresses relatively fast if left untreated (especially high grade lymphoma). The fact that it is May already seems promising in your case....I really hope all goes well in the follow up ultrasound appointment! Sending best wishes to Feeby!
 
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