My husband and I just put our one boy-cat, Bear on fluoxetine (Prozac) after he got over a bout of idiopathic cystitis due to the vet believing his condition was partly due to stress. We have him switched to an all wet food diet now (using dry food as treats) and just started him on Prozac 3 weeks ago. It was also recommended that we use Prozac due to territorial aggression with our female cat, Pig. With some behavior modifications, some extra play time and some treats for reinforcements they are now able to cohabit on the same room. The only problem is, he used to be super affectionate with me and in particular my husband. He wants nothing to do with my husband now and tolerates me well enough and will play with toys (da bird) and enjoys getting brushed. I'm wondering if he will always be so standoffish of if it is an adjustment period? Has anybody else had this same experience with Prozac and cats behavior changing so radically in this manner?