18.7 year old severe anemia, could this be vaccine associated Immune‐mediated hemolytic anemia (IMHA) or the like?

sillywoody

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Over the course of many years I have come here for advice with my beloved cat Silly and I have always gotten great support here along with his regular veterinary advice. At 18 years and 7 months old, I think his beautiful chapter is coming to a close.

While I’m accepting of this, I’m still wondering if this ending has anything to do with a 3-year non-adjuvanted rabies vaccine he got recently (PureVax), and if I have reason to bring it up to his veterinarian in thinking that it might help him in some way.

This will be long :(

April 30th he got the non-adjuvanted 3 year rabies vaccine in the tail at his annual. I live in a bat-infested area so it was a must.

Aug 28th a bat got into my home. Not knowing if it had rabies or had bit him, Silly was revaccinated with the 3 year non-adjuvanted (PureVax) rabies vaccine in the hind paw.

Around 1-3 days later, he urinated outside the litter box for the first time in his life. I now know between then and now he has gotten weaker and has had more trouble getting into his box, but at the time I thought was related to his arthritis.

September 30 he falls out of his box. I bring him to his vet. Blood test comes back that he is just borderline anemic. I don’t investigate too much still thinking he fell due to arthritis, and he seems to be better after falling within a few days and is walking normal for him again.

November 20 he tumbles on floor pillows, poops a regular bm after tumbling and vomits at the same time. Vomit looks like coffee grounds. He has labored breathing for about 5 mins. Then normalizes. He shortly thereafter has another bm that is black and tarry. (After bringing samples to the vet I now know the stool and vomit were very bloody.)

He is hospitalized for severe anemia for two days. Day 1 hematocrit is 19. Day 2 after fluids is 16.

Ultrasound finds an “incidental” liver tumor meaning not likely having to do with current gi bleeding. He is treated for gi bleeding. More ultrasound testing is possible. Radiologist says best case scenario is they find an operable mass. Due to risks associated with his age, I will not pursue surgery for him.

Plan for now is palliative care. We put a “bandaid” on to stop bleeding and he is on steroids. I’m not sure which steroid. Only med I have given since he is home is Sucralfate and his regular amlodipine/gabapentin.

He is home. Eating and drinking great (steroid induced I’m not sure?), using litter box, same level of lethargy maybe slightly improved.

Sadly, i think he smells metallic-y like blood. He had a bm yesterday that was at first black, soft formed then became much more light-brown normal looking at the end. Maybe the bleeding is stopped for now?

He has not purred once since he vomitted blood. Too weak to purr? In pain?

Planning for in-home euthanasia depending on how he does over next few days.

Could this be Vaccine associated Immune‐mediated hemolytic anemia (IMHA) or the like? Does it matter at this point? Is it too late? Is it even realistic to mention this without wasting my vets time? any knowledge re the treatment?

Of course I want a miracle and I want him better, I’m heartbroken but accepting that he is an old sick kitty and I still have the chance to give him a kind goodbye.

What are your thoughts?
 
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FeebysOwner

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You are probably somewhat in a territory of unknowns because of the double dose shot and how that could impact adverse effects. This is when consulting with an internal medicine vet, or even a vet university, might be of some benefit. So, you might want to ask your vet to do so.

Steroid induced or not, eating and drinking well is a good sign. If this were to be IMHA, steroids are usually given, so it sounds like the right first step. But, again, getting an internal med vet consult would be most helpful. I have heard that cyclosporine (ant-inflammatory) and immune-mediated disease treatments (possibly something like chlorambucil, which is also often used for cancer). Some will even treat with antibiotics as well.

What does your vet say about all of this? Are you going to have frequent blood work done to see if there are positive changes?

You are talking to one who has an 18+ yo cat recently diagnosed with cancer - along with her other diseases - and I do plan to do what I can to keep her around for as long as I can if she does OK. I'd say get a specialist involved and treat Silly to see if his condition can be reversed before concluding it might be his time to go.
 
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sillywoody

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Thank you for the advice. I haven’t mentioned it yet to the vet because I wasn’t sure if it was too unlikely. I will investigate this with the vet.
 

fionasmom

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Ask your vet anything that you want to know or that is bothering you. You don't need to mentally screen your own questions to make sure that you are not taking up their time or if the question is logical. If nothing else, you have paid this vet a great deal over the last 18 years, or whatever amount of time you have seen this particular vet. Asking for support at this crucial time is certainly owed to you. I would definitely investigate as was suggested.
 
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sillywoody

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I got to ask many questions including this one - his symptoms are not consistent with IMHA, which is a relief!

He will be getting rechecks as long as he sticks around for them, so hopefully, many more. His hematocrit is holding at 17 so we will work to bring that number up now that we stopped the gi bleed.

Please keep this sweet old man in your hearts and thoughts!

Thanks for your advice, FeebysOwner FeebysOwner fionasmom fionasmom
 
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sillywoody

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*Started a new thread with questions about Epogen and Aranesp in case anyone is looking specifically for that info it will be easier to find*
 
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