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This is heartbreaking. I'm not sure if there's a good answer. I really think vets have to be more cognizant of this and advise all of their customers about these dangers. It's probably best to bring them in together. Here's my guess--based on our experience. Initially, the hissing occurred after...

Context. In your house they have defined roles. Cats operate on a hierarchy--there's almost always a dominant cat--in this case Stuart. That doesn't necessarily mean aggressive. Outside, their roles/behaviors might be different. Not sure why Stuart does that to Maise, he may be reading her body...

We have two cats, a male (6 years old) and female (5 years old). They adore each other. The male recently got sick and made several trips to the vets. When he returned from his last visit, the female was very aggressive towards him and attacked. She had never done that before. It was distressing...