It absolutely helped with my beloved cats whom I had to airlift to safety internationally! Sprayed the carriers inside with Feliway (we'd lined them with pure foam that my ex got at Walmart) and they did not make a peep on the 100-mile journey, part of it over unpaved rocky roads, to the airport. They seemed quite calm at check-in and arrived calm and safe at the other end. Our vet had advised against tranquilizing, so we didn't. It is all credited to Feliway.