Gray Boy is estimated to be around 13 years old, and he had no known issues (other than a high liver value) when he suffered a urinary blockage 2 months ago. He was sent home with buprenorphine, Onsior, prazosin, but recovery was slow. He had struvite crystals so he was put on a prescription diet. A month ago I thought he had blocked again (growling and hissing in box, no urine output). The vet said he was not actually blocked but his bladder was still so inflamed, and he had a UTI confirmed by urinalysis. After one round of antibiotics he returned for another urinalysis and there was still a bit of bacteria left so he had another round of it. He also got some diazepam for use when I see him straining. Right now he is still on the prazosin and he takes the diazepam if he gets really bad, but I haven't seen it make him urinate any better. I also started him on cornsilk and D-Mannose supplements a week ago. None of this seems to be making any difference. Most evenings he is straining to urinate, growling, hissing, but by morning he is doing several quarter sized pee clumps. The vet continues to say it is just inflammation and I should keep doing what I'm doing. It just seems strange that his straining happens pretty predictably in the evening. I give him his prazosin in the morning, so maybe it's related to that, but then he is fine first thing in the morning before he has even received the morning dose that is meant to help him. He doesn't even have many crystals anymore, is eating only wet food, drinks water. I am stumped. I will of course keep following up with the vet, but I was wondering if anyone had any thoughts about this or ideas for what I could do to help him.