We have two spayed female cats, one is a 13 year old Ragdoll and the other is a 12 year old tuxedo cat. The Ragdoll cat has always been very skittish and the more moody of the two cats. The tuxedo generally has a very easy going disposition with her only downfall being she loves to eat. A little over a week ago, tuxedo cat had surgery and a teeth cleaning. The surgery was minor to remove a cyst. She was initially in a cone but now we have her wearing a baby onesie which seems to be working welll to keep her from scratching and licking the wound. She's a little off, more cuddly and tired but otherwise is doing well in her recovery. The problem is her sister the ragdoll. She hisses and growls at her incessantly. She cannot even walk by without her being growled at. She has not attacked her, I think she's afraid but poor tuxie is feeling bad already and does not need this. Tuxie does not respond in kind, and even when she's not injured she usually just ignores her sister. Ragdoll is usually like this maybe for a day or so after a vet visit, but NEVER this long. It does not matter if we take them together or not it still happens. We cannot bathe the tuxie due to the wound. We have tried the cat calming sprays, the cat calming plugs, putting the household smell on the tuxie, reintroducing them slowly, every single suggestion and are at our wits end. We live in a very small condo where the only two rooms that we could close her in are the bathroom or the closet. But they both share a little box (which they are using fine) and it would be hard short of getting two different ones (they don't like that) to keep them a part. But the ragdoll is becoming so aggressive and stressed that we are considering putting her in the closet when we are not at home, to protect the tuxie or sending her to stay with a friend. How can we fix this? Normally these cats get along really well, with a spat here and there, but they have been together since they were six months old. Ragdoll is acting like a little b word. She will hiss at us, and at her water bowl.