Rachel did not have FNA because vet doing ultrasound found no masses or prominent lymph nodes to aspirate. He said he believes this is a chronic condition and consistent with IBD. He kept her over night on iv fluids and Cerenia. I took her food over to the clinic last night and this morning the tech caring for her said she is bright and did eat some of the food. I will hear more from the vet later this morning. He said a biopsy could be done if I wanted it.I believe both Chelsea and Krista were suspected small cell lymphoma. This has a diffuse thickening appearance in ultrasound rather than a mass. This is likely what makes FNA inconclusive as the lack of cancer cells in the aspirate doesn't rule it out. If the vet suspects small cell lymphoma from the previous ultrasound, then yes, leukeran can be tried. In this case, you simply have to convince your vet that the diagnosis, the surgical biopsy, is riskier than the drug. However, if your vet isn't certain what type of lymphoma it might be, then he might not be willing to try leukeran if another would be more appropriate. I would ask your vet to put several options at the top of a sheet of paper and the risks underneath each: a) doing nothing, b) steroids only, c) steroids plus chemo, d) surgical biopsy, and e) chemo option B without the biopsy (in case leukeran may not be the best option depending on the type of cancer they suspect.) You might be able to put together an "informed consent" game plan, e.g. "I understand the risks of skipping the biopsy. Let's try our conservative options before our invasive options."
A helpful video from a vet explaining the difference between high grade (large cell)/low grade (small cell):
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