Feline Calicivirus and Lactoferrin

Antonio65

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My cat Giada was diagnosed (PCR) with Feline Calicivirus when she was around 4 months old. The vet wanted to run this test because of the redness of her gums, and test came back positive. I would like to have this test repeated in the next future, but until then I have to trust it.

Anyway, the cat is up-to-date with all her vaccinations, though this virus will never be defeated.
For four and a half years she didn't have any symptoms from that, the virus has been dormant, until a month ago when one day Giada didn't want to eat her dry food. This was a first, she never skipped a single meal in all her life, so this was the sign that something was off. She skipped the next dry meal as well, she would only eat the wet food, so I quickly took her to the vet who saw her gums reddish, no other signs in her mouth, nose or eyes, and told me to give her supplements for the infection, namely a supplement with Lactoferrin and L-Lysine, and a gel for soothing her gums.

After only two days of this treatment, Giada was feeling much better and resumed her meal habits. The treatment has to be continued for at least a month, and we're close to the end, but I would like to know whether it is a good idea to supplement her daily diet with Lactoferrin, say every other month.
The supplement I'm giving her now is oral drops which she dislikes a lot, so I'm looking for something to add to her meals, a powder. I only find powder in capsules, and I don't know if these capsules, once opened, are still effective and, above all, if the content can last long.

The drops I'm giving her now are 1 mg Lactoferrin (plus 4 mg L-Lysine) per dose, and the price is rather high, plus she doesn't like the taste. All the capsules that I find on the web are less expensive, but they are for human use and contain 200 mg Lactoferrin each, which I think is way too much.

Any comment and suggestion is welcome. Thanks!
 

FeebysOwner

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I really can't be of much help, if any - I guess it was my understanding that Lactoferrin was given orally in liquid form and applied in a manner that 'bathes' the mucous membranes of the mouth. Anything I have ever read of the powder version is to open the capsules and mix it with water to make a paste to apply to the inside of the mouth. I have also seen doses of 40mg/kg of body weight. If given orally elsewise, it seems it was more for the benefit of cats who were experiencing respiratory issues from FCV. There are ways to compound it, but I suspect it is not any more effective than most compounds in masking bitter tasting meds.

I have also read a lot of posts on this site where there doesn't appear to much benefit to lysine - but, like everything else, I am sure it varies by cat and their specific viral issues. There are others who use DMG as an immune boosting supplement.

This article will probably not help much either, but maybe - take a look at the section labeled 'Management of FCV Infection' which speaks about Recombinant feline interferon omega (feIFN-ω), among other items.
Frontiers | Update on feline calicivirus: viral evolution, pathogenesis, epidemiology, prevention and control (frontiersin.org)
 
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Antonio65

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I really can't be of much help, if any - I guess it was my understanding that Lactoferrin was given orally in liquid form and applied in a manner that 'bathes' the mucous membranes of the mouth. Anything I have ever read of the powder version is to open the capsules and mix it with water to make a paste to apply to the inside of the mouth. I have also seen doses of 40mg/kg of body weight. If given orally elsewise, it seems it was more for the benefit of cats who were experiencing respiratory issues from FCV. There are ways to compound it, but I suspect it is not any more effective than most compounds in masking bitter tasting meds.

I have also read a lot of posts on this site where there doesn't appear to much benefit to lysine - but, like everything else, I am sure it varies by cat and their specific viral issues. There are others who use DMG as an immune boosting supplement.

This article will probably not help much either, but maybe - take a look at the section labeled 'Management of FCV Infection' which speaks about Recombinant feline interferon omega (feIFN-ω), among other items.
Frontiers | Update on feline calicivirus: viral evolution, pathogenesis, epidemiology, prevention and control (frontiersin.org)
That article is really interesting, it explains so many things and aspects, some of them I didn't know, thanks!
The drops I'm giving my cat contain Lactoferrin and L-Lysine and should act from the inside, the way of action is systemic, that is they should boost the immune system to fight the infection, rather than soothing the symptoms locally.

I tasted those drops (I always taste all meds and supplements I'm going to give my cats) and that taste was awful, it was making me puke! I can understand why Giada hates them. That's why I was looking for an alternative, possible tasteless, and without the need to be given directly in her mouth.

After only a very few days, Giada was feeling better and resumed her meal habits. I don't know what contributed the most to her recovery, if one supplement or the other, or the combination of both.
Her gums still retain a reddish line on the very border to the teeth, and only at the rear of her mouth, on the last three or four teeth. As far as I remember, she always had that thin reddish line, since she was a kitten, and this was one of the reasons why I asked a PCR test for calicivirus. The other reason was her bad breath when she was a kitten.

She was given the same gel I'm applying now, so we're not new to it, but then I stopped because I saw that she wasn't needing it any longer. Two years ago I had her teeth cleaned, hoping to counter that reddish line of her gums, but it didn't help much.

As soon as I have the chance, I will ask the vet t run a second FCV test and see if it confirms the diagnosis.
 
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