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The patient brochure DOES talk about the risk of neurological abnormalities:
Because the isooxazoline class compounds are regulated by the FDA, all products containing them HAVE to include the warnings - so, it's not like the companies are voluntarily electing to display them. The cut-and-dried part is that most NON-isooxazoline flea treatments don't have warnings about neurological issues because 1.) studies don't support a potential risk, and 2.) they are not monitored by the FDA (so the studies conducted are a bit different than EPA approved treatments).It DOES look like the information is available to cat owners who want to know. It looks pretty cut-and-dried to me. The company doesn't seem to be hiding much if anything.
So... No, you can't say that one thing is better (or worse) because it is regulated by the EPA vs. the FDA... or vice-versa.CAS# 7664-93-9: WS5600000
LD50/LC50:
CAS# 7664-93-9:
Draize test, rabbit, eye: 250 ug Severe;
Inhalation, mouse: LC50 = 320 mg/m3/2H;
Inhalation, mouse: LC50 = 320 mg/m3;
Inhalation, rat: LC50 = 510 mg/m3/2H;
Inhalation, rat: LC50 = 510 mg/m3;
Oral, rat: LD50 = 2140 mg/kg;
.
Carcinogenicity:
CAS# 7664-93-9:
- ACGIH: A2 - Suspected Human Carcinogen (contained in strong inorganic acid mists)
- California: carcinogen, initial date 3/14/03 (listed as Strong inorganic acid mists).
- NTP: Known carcinogen (listed as Strong inorganic acid mists).
- IARC: Group 1 carcinogen
Epidemiology: Exposed industrial workers showed a statistical increase in laryngeal cancer. This suggests a possible relationship between carcinogenesis and inhalation.
Teratogenicity: Not teratogenic in mice and rabbits, but was slightly embryotoxic in rabbits (a minor, rare skeletal variation). The animals were exposed to 5 and 20 mg/m3 for 7 hr/day throughout pregnancy. Slight maternal toxicity was present at the highest dose in both species.
Reproductive Effects: No information found
Neurotoxicity: No information found
Ecotoxicity:
Fish: Bluegill/Sunfish: 49 mg/L; 48Hr; TLm (tap water @ 20C)
Fish: Bluegill/Sunfish: 24.5 ppm; 48Hr; TLm (fresh water)
Just because a product is regulated by the EPA instead of the FDA, it doesn't mean that the rules are any easier. They just focus on different things.
I am somewhat confused by some of your comments. I don't recall suggesting EPA's rules are easier, and did denote that the FDA and the EPA are looking at products from different perspectives. I also don't recall saying that one thing is better (or worse) because of who regulates it.So... No, you can't say that one thing is better (or worse) because it is regulated by the EPA vs. the FDA... or vice-versa.
So, just curious, what would your vet have to tell you to convince you that Bravecto is safe??If Casper's vet was to recommend a flea treatment like Bravecto, you can bet dollars to donuts that I'd be raking her over the coals. If she didn't answer my questions to my satisfaction, I would NOT be giving such a medicine to Casper.
I am exactly the same way. And, I treat my pets in the same manner.I'm the kind of person who hesitates to take aspirin or cold pills unless I feel like I really need them.
Did that...I would ask her what the medicine is, how it works and why she thinks it's better than another kind of medicine.
Did that...I would read the patient brochure and the doctor's prescribing information if I can get it.
Did that as well - my vet said he has never seen any neurological adverse reaction in animals who have taken Bravecto, the cases on file are extremely isolated, and he gives Bravecto to his own cats.I would ask her about side effects and adverse reactions. I would ask her if she's actually seen any cats with these reactions and I would ask her how well those cats recovered from the effects.
I can't say a B.S. detector went off, as I do trust my vet - always have. But, my "I just can't risk it with Feeby" detector went off.If the B.S. detectors are quiet, if the vet's reasoning sounds good and the literature reads well, I'll be likely to take the recommendation.
Feeby is 100% indoor cat and we have not had fleas for over 30 years. So, it is my assessment that it can happen at any time - based on current events.He's a 100% indoor cat. My neighbors cats are also indoor cats and they are kept clean so they are less likely to get fleas.
There is no winding down of flea season in my area.Flea season is winding down in my area.
I have always kept my house clean and my cat(s) indoors and away from other animals. And, it worked for over 30 years - until now. So, as I said before, apparently it CAN happen to anyone at any time - despite one's diligence.If you keep your house clean and don't let your cats come into contact with fleas, in the first place, you won't have to worry so much about flea medications or their possible side effects.