Experience with Mirtazapine?

bananamillie

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Hi folks, wanted to see if anyone has used Mirtazapine (either pill or gel) for their cats, and seen results?

Our vet has prescribed Mirtazapine for our 13 yr old cat diagnosed with early kidney disease because she wouldn't eat large amounts of her kidney food.
I'm sure this had nothing to do with her appetite, but rather her preferences. The vet insisted that she stay on the kidney diet and use Mirtazapine to get her to eat more of it.
This has not worked out great. Cat is now hungry and upset that she's not getting the food she likes.
I'm now switching her onto non-vet food which is higher in protein but low phosphorous.

I'm also seeing a dip in her appetite once the Mirtaz wears off. She has not been thrilled about eating in general since we tried to switch her food up few weeks ago.
She was doing great till then.

Does anyone have any experience or insight on the following -
- How long can a cat stay on Mirtazapine?
- Has it stopped working at any point?
- I may be paranoid, but I'm noticing that she's drinking less water after taking it. Has anyone experienced this?
- Any side effects to watch out for?
 

fionasmom

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I have only used mirtazapine (often) over the years in cats who did not have a good prognosis but for whom we were trying to buy a little time. They were all probably more ill than your cat, not necessarily with kidney disease. As such, it was only used in the short term but I did notice a dip in appetite when it stopped.....whether due to worsening condition or withdrawl of the drug is uncertain. It has never been given to me to encourage a cat to eat food that was not appealing.
 

kittenmittens84

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My cat was prescribed transdermal mirtaz when he was sick with FIP and didn’t want to eat due to nausea. It worked ok on its own, but it worked far better once we added in an anti-nausea med as well. No side effects that I noticed, although the vet did warn us that the oral version can cause tremors in some cats which is one reason they usually use the ear gel form.
If you’re concerned about water intake and she’s eating wet food it’s probably fine but you could always mix a spoonful of water into her food.

As far as food palatability goes, some cats seem to really like Fortiflora probiotic powder, enough that people will recommend sprinkling it on food to entice picky cats to eat.
 
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bananamillie

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Furballsmom Furballsmom Thank you! I will read through those threads :)

fionasmom fionasmom Thank you! We paused her oral dose for a day and there was an immediate dip in appetite so we had to start her on it again. We're just trying to feed her food that she likes at this point but she's really unhappy with the diet changes. She licks a bit at Weruva but will only enthusiastically eat Beechnut turkey baby food.

K kittensmittens1373 Thank you for sharing! We currently have her on the oral pills, but only because the vet didn't have the gel and we had to order it from Chewy. Still waiting on it to arrive. We've tried Fortiflora, but didn't get the sense that she was eating more because of it.
 
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bananamillie

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K kittensmittens1373 Did your kitty have nausea due to mirtazapine? Our cat has been extremely lethargic 72 hours after her 2nd dose (which had probably worn off at that point). Not much of an appetite and hyper salivation.

Ended up taking her to emergency where they gave her an anti nausea shot and nausea pills to give her over the next few days.
They didn't see any cause for concern but I am quite worried as she is extremely lethargic.
She apparently ran across the floor at the vets and jumped into a bookcase, which I will chalk up to adrenaline. She's not moving at all at home other than to adjust her resting position.
 

Furballsmom

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You could possibly take a video and show the vets what little activity she's doing. Hang in there!!
 

amandag1

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Hi folks, wanted to see if anyone has used Mirtazapine (either pill or gel) for their cats, and seen results?

Our vet has prescribed Mirtazapine for our 13 yr old cat diagnosed with early kidney disease because she wouldn't eat large amounts of her kidney food.
I'm sure this had nothing to do with her appetite, but rather her preferences. The vet insisted that she stay on the kidney diet and use Mirtazapine to get her to eat more of it.
This has not worked out great. Cat is now hungry and upset that she's not getting the food she likes.
I'm now switching her onto non-vet food which is higher in protein but low phosphorous.

I'm also seeing a dip in her appetite once the Mirtaz wears off. She has not been thrilled about eating in general since we tried to switch her food up few weeks ago.
She was doing great till then.

Does anyone have any experience or insight on the following -
- How long can a cat stay on Mirtazapine?
- Has it stopped working at any point?
- I may be paranoid, but I'm noticing that she's drinking less water after taking it. Has anyone experienced this?
- Any side effects to watch out for?
While kidney diets are great, if she was doing fine maybe looking for low phosphorus foods but still giving her some of what she likes may be best.
A fed cat is better than a cat refusing to eat.... kind of like fed is best in the breastfreeding/ formula discussion.
 

amandag1

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Ive also had my boy on mirtazepine daily- the pill. I give him the 7.5mg cut into FOURTHS. So he gets about 1.87 mg and this works way better with less drowsiness and weird behaviour than 3.25 mg every other day (which is what the vet wanted..)
I read a paper saying more adverse effects are seen at the higher dose so cutting it into 4th works good , or MIRATAZ gel does about 1.88 mg delivery via transdermal gel.
The gel unfortunately made my boys ears get dry and scabby so we went for the pill.
 
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bananamillie

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Turns out the Mirtazapine was not great for our cat.

She had really strange behavior 36-48 hours after giving her the Mirt., even on a small dose.
Her first dose was uneventful, but after the second and third dose she had bouts of extreme lethargy followed by extreme restlessness and hyper-salivation.
Although her appetite did improve soon after the dose, the strange behavior was enough for us to stop giving her the Mirt.
 
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