Cat Vomiting/diarrhea 24+ Hours After Mirtazapine?

tyegarcas

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Hi,

My cat just completed her fifth and final chemotherapy session about 3 weeks ago after developing mammary cancer. She's been looking quite skinny and she's been very picky with her food, so her vet prescribed Mirtazapine, given that the previously prescribed Ondansetron wasn't having any effect on her appetite. She was also prescribed Metronidazole to prevent diarrhea during chemo, but I never had reason to use it the whole time she was in treatment.

I had been holding off on dosing her with the Mirt since I know my way quite well around antidepressants and didn't want to give this to my cat. However, she was hardly eating, so yesterday I caved and gave her 1.88mg at around 3:30 PM.

Since then, she's been great! She's been eating heartily and I was quite encouraged. However, just 30 minutes ago, an entire 30 hours later she threw up quite a bit. Plus, she's been having really soft, watery stool all day that just turned into diarrhea.

She's still asking for food but at this point, I'm afraid it'll just make her throw up more. Should I try dosing her with the metronidazole at least to prevent diarrhea? I don't know if I should dose her with Ondansetron to help with the vomiting - I thought the Mirtazapine was already an anti-emetic.

I'm at my wit's end here, what do I do?!
 

Daisy6

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Welcome to TCS! You have some good questions.

I call the drug meowsapine because its side effect on my cat (which the vet warned me about) was loud and frequent meowing, which lasted two days. She threw up a few minutes after swallowing the pill four times (which is known to happen) but not randomly. The only other drug she took was Pepcid AC (original), which had no side effects.

Does your vet know when she throws up and has loose or runny stools?
 
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tyegarcas

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Thank you for responding!

She did meow a bit when she was first given the Mirt but otherwise she had been normal. The only thing I that I can think of is that maybe she gorged herself? She had been eating maybe half a small Fancy Feast can a day if that, and today she had already eaten a full can of food by 5 or so, at which point I opened another since she seemed hungry.

I haven't talked to my vet yet because it just happened a little more than two hours ago and it's 12 am here, but Bella will have loose/runny stools when she eats a lot of wet food which is what's happening here. I'm more worried about the random vomiting, to be honest.
 
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